Cerium dioxide nanoparticles exacerbate house dust mite induced type II airway inflammation
نویسندگان
چکیده
منابع مشابه
TGF-β Regulates House Dust Mite-Induced Allergic Airway Inflammation But Not Airway Remodeling
“At a Glance Commentary” The current dogma, based largely on indirect evidence, is that TGF-β plays a prominent role in the development of airway remodeling, a recognized feature of chronic allergic asthma. This research contributes to our understanding of the mechanisms regulating inflammation and remodeling in chronic allergic asthma, and suggests that therapeutic strategies to prevent remode...
متن کاملTransforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling.
RATIONALE It is now believed that both chronic airway inflammation and remodeling contribute significantly to airway dysfunction and clinical symptoms in allergic asthma. Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis o...
متن کاملEndoplasmic Reticulum - Mitochondrial Interactions in House Dust Mite Induced Inflammation
Rationale: Airway epithelial cells (AECs) are critical regulators of inflammatory, immune and injury responses to allergens that contribute to asthma pathogenesis. The response of AECs to allergens requires an integrated-complex, extracellular receptors and intracellular organelle interaction to achieve secretion of pro-inflammatory cytokines and chemokines. Endoplasmic reticulum (ER) and mitoc...
متن کاملTIM-3 is not essential for development of airway inflammation induced by house dust mite antigens
BACKGROUND T cell immunoglobulin domain and mucin domain-containing molecule 3 (TIM-3), which is preferentially expressed on Th1 cells rather than Th2 cells, is considered to be a negative regulator of Th1 cell function. This suggests that TIM-3 indirectly enhances Th2-type immune responses by suppressing Th1 cell function. METHODS To investigate TIM-3's possible involvement in Th2-type acute...
متن کاملSchistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice
The "hygiene hypothesis" is a theory try to explain the dramatic increases in the prevalence of autoimmune and allergic diseases over the past two to three decades in developed countries. According to this theory, reduced exposure to parasites and microorganisms in childhood is the main cause for the increased incidences of both T helper 1 (Th1)-mediated autoimmunity and Th2-mediated allergy. I...
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ژورنال
عنوان ژورنال: Particle and Fibre Toxicology
سال: 2018
ISSN: 1743-8977
DOI: 10.1186/s12989-018-0261-5